There are a total of 33 runes in the game; D2R Powerleveling can farm El Rune as early as Act 1 Normal, and the highest tier Zod Rune can be obtained in Act 5 Hell, with the lowest tier El Rune being obtained as early as Act 1 Hell. Farming Runes can be accomplished in the following ways:
Kill as many monsters as can.
More chests should be opened.
Completing certain quests is required.
Making Horadric Cube Recipes from Scratch
More monsters are being killed, and more farming spots are being discovered.
One of the most effective methods of farming runes is to kill more monsters, resulting in more total items being dropped. It's important to note that Magic Find has no effect on rune drops, either in terms of quality or volume.
All monsters of the appropriate level have a chance to drop Runes, though it is a rare occurrence in the game. In fact, there are only a few types of monsters and events with an increased chance of dropping Runes, and it is difficult to target them using any criteria other than "the higher your chance of obtaining Runes."
The Pit is a level 85 area with easy enemies, and level 2 always has a Golden Chest in it. This is referred to as a Pit Run in most circles.
The Ancient Tunnels are a Level 85 area with no Cold Immune monsters and a Golden Chest that is always present.
Chaos Sanctuary is a level 85 area with a high density of monsters and a large number of unique monsters. It's a little difficult.
World Stone Keep is a level 85 area with a high density of monsters and a large number of unique monsters. This is the most difficult.
The Secret Cow Level/Moo Moo Farm is located in a level 81 area with a high density of cows. There are no monster Immunities, making it difficult for melee builds.
Great farming spots are typically characterized by high monster density, which increases the number of boss packs that can be killed while decreasing the amount of time spent traveling between enemies.
The Countess, who can be found on level five of the Forgotten Tower in the Black Marsh level of Act One's Black Marsh level, is the only monster in the game with a significantly higher percent chance of dropping runes.
Because they cannot drop armor or weapons, a few monster types have a higher chance of dropping runes than others. As a result, they spit out more runes than other monster types because they have fewer other possible drops. Wraiths, Finger Mages, Vulture Demons, Willowisps, and the Swarm are examples of such creatures. These monsters are worth harvesting while rune farming, but because they spawn infrequently and in small numbers, only a small number of players will consider D2R Items Xbox worthwhile to put in the effort for the slight increase in the likelihood of finding runes.
Chests of drawers
A low chance of receiving runes from Good treasure chests is present as well. Chests are any and all objects that have the ability to hold an item. Bodies that can be looted, hidden stashes, and other such items are examples of such items. These items have varying drop rates as well as varying quality of item drops.
Chest runs in areas with a large number of chests are a great way to find a large number of high-quality items, particularly runes, in a short period of time. All chests are potentially useful, but super chests are the ones to seek out; for example, you'll come across a couple near the campfires in Lower Kurast in Act 3 and one near the campfires in Lower Kurast in Act 4.
Lower Kurast Super Chest: There are a total of six Super Chest in Lower Kurast, each of which can yield anything from a Ber Rune to a Ber Rune and more. In single-player, one of the most effective methods for farming up to Ber runes is to use a swarm of wolves.
There are a large number of "super chests" in the game, which are chests that can drop multiple items at the same time. The majority of super chests are sparkly chests, but this is not an absolute rule. Not all super chests sparkle, and not all super chests that sparkle are also super chests.
For example, some sparkly chests are quest chests that contain quest items, while others are simply decorative. The Maggot Lair chest, the Spider Cavern chest, the Kurast Lvl 2 chest, and the Ruined Temple chest (Lam Esen's Tome) are among the treasure chests available. These are not the real deal when it comes to "sparkly chests."
There are 24 Sparkly Chests in each difficulty level, for a total of 72 Sparkly Chests on the Path to Hell difficulty Baal, which is the hardest difficulty. In the False Tal Rasha's Tombs, there are five chests that have the same characteristics as one another. The Great Marsh is home to two Sparkly Chests, both of which have the same characteristics. Because they are encountered on three different difficulty levels: Normal, Nightmare (NM), and Hell 
, the drop odds for the remaining 17 chests are unique to each of them.
